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Hyperglycemia creates oxidative stress, inflammation, vascular damage overwhelming isolated peptide interventions unless glucose controlled

Effect of constant and variable domain glycosylation on pharmacokinetics of therapeutic antibodies in mice

"Can You Take Too Much Vitamin B?"
2003 Mar 25;60(6):935-40
And how can biology thread the needle between reaching for cellular immortality, and the potential malignant consequences
McKay PG, Walker H, Martin CR, Fleming M