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When glucose levels are low or when energy demand is high, sympathetic pathways may stimulate the release of fatty acids through receptor signaling pathways involving PKA/PKG, PKC, tyrosine kinase, and ERK1/ERK2 (Zechner et al., 2017)

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The gastrocnemius muscle tissues from mice were homogenized and solubilized in RIPA lysis buffer (Beyotime, China)

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In these athletes, LC is thought to promote the usage of fat in energy generation, preserving some of the muscles natural energy source, therefore delaying the point when they hit the wall. 16 17 Interestingly in a rat model, ALCAR and alpha-lipoic acid co-supplementation was able to improve metabolic function, burning energy more efficiently, whilst also reducing oxidative stress

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First, the main criterion for inclusion was the identification of P/LP variants in the SLC22A5 gene

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