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Gould TD, Manji HK

Further, vanaspati ghee contains large amount of trans fatty acids as compared to coconut oil 1

Biomolecules 9 , 22 (2019)

A terminal metabolite of niacin promotes vascular inflammation and contributes to cardiovascular disease risk

In this cells, the apoptotic pathway relied upon the same Trx1/p38MAPK/p53 signaling axis and cell survival to diamide relied upon redox activation of NE2FL2, in a way independent of Keap1 oxidation, but responsive to ERK1/2 activation (Filomeni et al., 2012)

That difference medical-grade and monitored versus unregulated and alone is the single biggest safety factor in the whole conversation