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We found that irrespective of the route of vitamin B12 administration, serum vitamin B12 levels were increased

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CB activates the ERK-AP-1 pathway through TLR2, inducing TGF-1 in mouse lamina propria DC (LPDCs) to promote iTreg generation (100)

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This bioactive form of folate is more easily absorbed by the body, making it a more effective choice than synthetic folic acid

Functional experiments confirmed that knocking down p21 expression in a DMM surgery-induced mouse OA model exacerbated articular cartilage degradation and was accompanied by a significant decrease in GPX4 protein levels in vivo , demonstrating that p21 plays an important anti-ferroptotic role in OA progression by modulating GPX4 stability (Zheng et al., 2024)