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While the clinical phenotype observed in Papillon-Lefvre syndrome (PLS) necessitates careful monitoring of skin and periodontal health during DPP1 inhibition therapy, clinical trials have shown these adverse events occur at low frequencies (1%4%) and are predominantly mild to moderate in severity

[DOI] [PMC free article] [PubMed] [Google Scholar] 46.Hsieh M.J., Liu H.T., Wang C.N., Huang H.Y., Lin Y., Ko Y.S., Wang J.S., Chang V.H., Pang J.S

Chronically elevated glucose levels are also associated with an elevated risk of developing type 2 diabetes

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