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Many of these current therapies have important limitations including inadequate efficacy and undesirable adverse events (AEs)

This is an important characteristic of sperm that promotes the acrosome reaction

Moreover, due to its ability to recognize and interact with ubiquitin, p62 connects ubiquitinated proteins to the autophagic machinery, facilitating their degradation through selective autophagy 23,24,25

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This ensures the best treatment outcome

ANGPTL8 promotes the ability of ANGPTL3 to bind and inhibit lipoprotein lipase
