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Intrapatient changes in CT-based body composition after initiation of semaglutide (glucagon-like peptide-1 receptor agonist) therapy

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doi: 10.1186/s12917-019-2227-8

Similar content being viewed by others Main The development of long-acting pharmacotherapies based on the incretin hormonesglucagon-like peptide-1 (GLP-1), glucose-dependent insulinotropic peptide (GIP) and glucagon (GCG)has been transformative for the treatment of cardiometabolic diseases such as obesity and type 2 diabetes (T2D) 2,7,8,9,10,11

Potential for stronger effect: Because the bioavailability (the fraction of the administered dose that reaches circulation) can be higher via injection, the impact on sleep architecture (e.g., slow-wave sleep increases) may be more pronounced