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We used the GEO accession number GSE178265 to download single-cell data in the GEO database ( Annotated information of cell types was also downloaded from the Broad Institutes Single Cell Portal ( PD-related bulk RNA-seq data (GSE49036, GSE20164) was downloaded and viewed in the GEO database

The chemical structures of the associated botanical drugs are shown separately in the figure (Figure 3)

Pentoxifylline also inhibits neutrophil adhesion (Hendry et al., 2020)

A missense variant in mitochondrial Amidoxime reducing component 1 gene and protection against liver disease

The resulting positive and negative ion data were combined into a data matrix table

IGF1 is a singlechain polypeptide growth factor 28, 29, 30 that is related to insulin and IGF2 31