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50 Annular stabbing with needles in animal model consistently triggers disc degeneration, characterized by loss of disc height, hydration and proteoglycans and by the expression of inflammatory, catabolic and fibrotic proteins

It is important to recognize that while the disease affects the SN neurons and cause the classical symptoms, other brain regions, such as respiratory nuclei, also undergo degeneration

We also need to be immunologically flexible

Or they give vague instructions like "add bacteriostatic water and inject" without specifying exactly how much water creates what concentration

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Role of proton-activated G protein-coupled receptors in pathophysiology