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In most diseases, ROS appear to have a direct connection with inflammaging and cell senescence, and oxidative stress and inflammaging increase the aging-related phenotype, and induce and aggravate the inflammatory response, creating a chronic state of systemic inflammation (290297)

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GSTs have also been shown to exhibit GSH-dependent peroxidase activity and thus may be involved in resistance to oxidative stress

10.1097/cad.0000000000000337 78 KudelaP.PauknerS.MayrU

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