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Clinical investigation to support new uses generally requires an Investigational New Drug (IND) application with appropriate chemistry, manufacturing, and controls, nonclinical safety, and human data

Pharmaceutical preparations of vitamin B 12 may be given by intramuscular injection

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Canadian Medical Association Journal 2013;185(4):E20111

VB 12 Repairs Mitochondrial Dysfunction Related to Oxidative Stress by Activating the CBS/SIRT1 Axis The silencing of CBS-mediated mitochondrial dysfunction in endothelial cells has been studied, and vitamin B 12 is necessary for the tricarboxylic acid cycle [26], that is, to maintain the function of mitochondria in cells