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Liu Q, Jia Z, Duan L, Xiong J, Wang D, Ding Y

When not properly dealt with, excessive peroxynitrite formation can result in increased oxidative stress and vascular inflammation (Esposito and Cuzzocrea, 2009)

The selective inhibitor compound 27 (IPN60090), which is currently in a first-in-class clinical trial, focuses on optimising physicochemical and pharmacokinetic properties, with a strong in vivo target engagement capability, and should strongly inhibit GLS in humans [152, 153]

WCS NPs, comprising diamond, graphite, fullerenes, and amorphous carbon particles, offer excellent UV absorption, high graphitic quality, efficient D/I, low background signals, reproducibility, sensitivity, and stability, surpassing those of other metal- and carbon-based matrices

In mice model single dosage of 150 mg per kg of cyclophosphamide was administered intraperitoneally then different icariin doses were administered intraperitoneally such as 5 mg, 25 mg, and 50 mg per kg were shown to reduce visceral reflexes and nociception

The effectiveness of therapeutic strategies targeting histone lactylation sites in mitigating IRI and facilitating the recovery of associated functions has been validated in several studies [20, 37, 38]