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Elevated plasma TMAO concentrations predict incident CVD risks in multiple clinical cohorts (47, 914), and both animal models with microbial transplantation (4, 15) and various studies on mice and humans with raised TMAO have revealed mechanistic and prognostic links between microbial TMAO production and both atherosclerosis and thrombosis, as well as chronic kidney disease and heart failure (46, 12, 13, 1618)

Further to this it has been suggested that supplementing with 2g daily for 4-weeks has been associated with an improvement in VO2max in long distance runners 8

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Abrahamsson, P., Tauson, R

Stanley CA: Carnitine deficiency disorders in children

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