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Gene Expression Modulation Transcriptomic analyses in cellular models have shown that GHK-Cu influences expression of a remarkably wide set of genes, with reported effects on pathways involved in: Extracellular matrix remodeling DNA repair Antioxidant response Inflammatory signaling Stem cell signaling markers This broad transcriptional footprint has been one of the most studied aspects of GHK-Cu in recent years

The acid-sensitive, anesthetic-activated potassium leak channel, KCNK3, is regulated by 14-3-3-dependent, protein kinase C (PKC)-mediated endocytic trafficking

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