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1 Introduction Age-related macular degeneration (AMD) is a severe retinal disorder, affecting over 200 million patients over 50 years old globally (Wong et al., 2014)

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TGF-1 exerts its biological effects via the heterodimerization of two transmembrane receptors, TGF- receptor Type I (TGF-RI) and Type II (TGF-RII) [14], and it can induce both canonical (Smad-dependent) and non-canonical (non-Smad-dependent) signalling pathways, which result in activation of myofibroblasts, increase of ECM production, and inhibition of ECM degradation [15, 16]

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