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Under normal conditions, Nrf2 is anchored in the cell cytoplasm by a repressor protein called Keap1

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Immune response One theory relates to overactive immune response

Simultaneously, it upregulates the expression of the transferrin receptor (TfR), intensifying iron absorption in liver cells and resulting in hepatic iron overload

The real answer is far more nuanced and, honestly, far more interesting

On day 12, mice were subjected to a 4 h fast period, then deeply anesthetized using isoflurane and trunk blood was collected by decapitation