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Dufrusine B, Valentinuzzi S, Bibbo S, Damiani V, Lanuti P, Pieragostino D, et al

Unlike AMPARs and NMDARs, which drive the bulk of synaptic transmission, KARs are thought to play more specialized, modulatory functions in both the pre- and post-synaptic compartments where they control different forms of plasticity 1,4,5

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The role of lactate is to modulate neural redox state and energy metabolism, which then serves to indirectly enhance NMDA receptor activity, thus facilitating downstream calcium signaling and synaptic plasticity [100,103,105]