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In T1DM, autoantibodies show specificity for binding two variants of ZnT8 (R or W at amino acid 325) dictated by a polymorphism in SLC30A8 [43]

Conversely, lytic cell death is highly inflammatory, such as pyroptosis, necroptosis, and necrotic extracellular traps (NETosis) [66]

GONZALEZ-CABEZAS, Indiana University School of Dentistry, Indianapolis, IN 24

Mushrooms: a rich source of the antioxidants ergothioneine and glutathione

You can get good at anything

While the concept is in line with improving the key pathobiological defect in neurodegeneration (locus coeruleus degeneration, reduced noradrenergic innervation and decreased L-lactate production), further developments are needed to bring the proposal to a feasible clinical outcome