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J Clin Investig 117(3):636647 Valdez-Morales EE, Overington J, Guerrero-Alba R, Ochoa-Cortes F, Ibeakanma CO, Spreadbury I, Bunnett NW, Beyak M, Vanner SJ (2013) Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2

Also, L-Arginine increases blood flow, therefore its also beneficial to support heart health, lower blood pressure, and for erectile dysfunction

TNF- disrupts the BBB by inducing C-X-C motif chemokine ligand 10 (CXCL10) secretion and promoting peripheral T lymphocyte infiltration

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Thompson J