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and Shai, Y., Biopolymers , 1998, vol

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Gastrointestinal symptoms (more common with oral preparations): Mild nausea or upset stomach Diarrhoea (typically with very high doses) Other effects: Headache, particularly when treatment is first initiated Dizziness or light-headedness Skin reactions such as mild rash or itching Temporary reddish discolouration of urine (chromaturia) after hydroxocobalamin injections, which is harmless It is important to note that many symptoms attributed to B12 supplementation may actually represent the body's response to correcting a deficiency

For instance, abnormal accumulation of succinate or specific lipids from stressed neurons could act as eat-me signals, triggering phagocytic activity in microglia

doi: 10.1038/sj.onc.1208475

These results were confirmed by studies demonstrating that human STAT5B mutations also cause severe growth failure due to GHI and also demonstrating the critical role exerted by STAT5b signaling in GH-induced IGF-1 production and in normal linear growth (56)