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doi: 10.1002/jcp.24781 98 ZengXZhuMLiuXChenXYuanYLiLet al

10.1006/mthe.2002.0627 11 BrandM

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Furthermore, increased strand breaks generation caused activation of poly(ADP-ribose) polymerase (PARP), a zinc finger DNA-binding protein, known to deplete intracellular NAD + reserves as well as energy stores, thus ultimately resulting in cell death (429)

Following 24 h incubation at 37C in media containing 10 M of compound, cells were fixed with a cold 1:1 solution of methanol and acetone for 20 min at -20C

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