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Description

For autoimmune hemolytic anemia and some types of inherited blood disorders, splenectomy (surgical removal of the spleen) may be recommended in some patients

Technically, but it wasn't designed for that purpose

We found that postnatal vB12 treatment corrected some of the metabolic alterations and it eradicated the PPI deficits

(1) Groups at Risk of a Potential Vitamin B12 Deficiency Some people are at a higher risk for B12 deficiency, including those who: Have celiac disease, Crohns disease (a gastrointestinal disorder that can impact B12 absorption), or HIV Regularly take antacids, proton pump inhibitors, or other gastric acid inhibitors (these medications reduce gastric acid secretion and can interfere with vitamin B12 absorption, increasing deficiency risk) Follow vegan diets (vegan diets lack sufficient vitamin B12 sources, as B12 is mainly found in animal products) Are exclusively breastfed infants of women on vegan diets (these infants are at risk of B12 deficiency due to low maternal B12 intake)

In these cases, your doctor may request additional tests to assess functional B12 status: Methylmalonic acid (MMA) : Elevated levels suggest tissue B12 deficiency, as B12 is required to metabolise MMA (note that renal impairment can also raise MMA levels) Homocysteine : Raised homocysteine can indicate B12 or folate deficiency (also affected by renal function) Holotranscobalamin (active B12) : Measures the biologically active fraction of B12 [4] [8] Full blood count : May reveal macrocytic anaemia (enlarged red blood cells) characteristic of B12 deficiency If B12 deficiency is confirmed, your doctor will likely investigate the cause with tests such as intrinsic factor antibodies (and sometimes parietal cell antibodies) to check for pernicious anaemia, or coeliac serology if malabsorption is suspected