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In the context of obesity, vitamin A supplementation significantly improved vitamin A levels in the lungs of diet-induced obese mice, decreased inflammatory cytokines in the blood and improved antibody responses after vaccination against the influenza A (H1N1) virus, thereby promoting a reduction in viral loads post challenge (82)

Diet vs Disease

ROS concentration may be enhanced for many reasons of both an internal or external nature, such as inflammation or exposure to xenobiotics

For instance, 2-DG synergizes with Etoposide to increase cytotoxicity, promote tumor-specific T-cell activation, and induce immunogenic cell death

Medical Journal of Chinese Peoples Liboration Army 39:470474 Guo C, Guo D, Fang L, Sang T, Wu J, Guo C, Wang X (2021) Ganoderma lucidum polysaccharide modulates gut microbiota and immune cell function to inhibit inflammation and tumorigenesis in colon