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Suppression of CHOP reduces neuronal apoptosis and rescues cognitive impairment induced by intermittent hypoxia by inhibiting bax and bak activation

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Through in vitro and in vivo studies, it has been confirmed that CAR-T cells expressing this system have significant differences in killing non-tumor cells expressing normal amounts of HER2 and tumor cells expressing 100 fold HER2 (53)

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10.1186/s12985-019-1182-0 137

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725 An important mediator of the autophagy-enhancing effects of mTOR inhibition is the activation of TFEB, a transcriptional regulator recruited to lysosomes and phosphorylated by mTORC1, leading to its sequestration by 14-3-3 proteins

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In such cases, MMA concentrations in urine should be adjusted for creatinine excretion (Norman & Morrison, 1993) and the ratio of urinary MMA to creatinine (uMMA/C) applied to assess B12 status

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