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Oxidation of macromolecules is triggered by excess ROS, which in turn triggers cell death by releasing cytochrome c (Cyt-c) (82)

doi: 10.1161/01.RES.0000232321.89714.0e

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P53 loss inhibits the nuclear accumulation of DPP4 and thus facilitates plasma membrane-associated DPP4-dependent lipid peroxidation, which eventually leads to ferroptosis

Importantly, new avenues of research highlight that a fundamental booster of the functional effects of fish oil supplementation is physical exercise and, in particular, strength training