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Overall, the least-squares mean change in HbA1c (%) from baseline to week 12 was greatest (at 0.95%) in Cohort B participants, who received ORMD-0801 8 mg once and twice daily

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Kidney In diabetic nephropathy, MGO contributes to the formation of AGEs, which exacerbate oxidative stress and inflammation, leading to damage to the renal glomeruli and tubules [267,268]

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Liver function enzymes in serum, hepatic oxidative stress, proinflammatory cytokines, apoptosis, and ER-stress biomarkers were assessed

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