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[DOI] [PubMed] [Google Scholar] 238.Hara T., Toyoshima M., Hisano Y., Balan S., Iwayama Y., Aono H., Fatamura Y., Osada H., Owada Y., Yoshikawa T

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Biochimica et Biophysica Acta, 1830: 32893303

The phase II clinical trial NCT01817751 is evaluating the activity of sildenafil and other drugs (sorafenib and valproic acid) in patients with recurrent high-grade glioma (147, 148), whereas the clinical trial NCT02279992 is evaluating the use of vardenafil to increase systemic concentration of carboplatin in patients with recurrent malignant gliomas or metastatic brain cancer

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Real-world biomarker estimates suggest GLP1 monotherapy typically achieves 815 % weight loss over 612 months, while TRT alone may lead to 38 % increases in lean body mass