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M., Fontella, F

2016;310(1):G26-33

Amidst COVID-19 pandemic, two mRNA vaccines, the BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), have been granted Emergency Use Authorization by the United States Food and Drug Administration (FDA)

doi: 10.1155/2022/3972829

Taraseviciute A, Voelkel NF

Despite having several advantages like high transduction efficiency and the potential for long term transgene expression, viral vectors have certain disadvantages like increased immunogenicity (LV), prevailing cytotoxicity (LV), a small packing size (AAV), expensive large scale production (all vectors), and the risk of integrating viral sequences into the target genome (LV) 8
