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eLife 2014

The molecular sequence of this unknown substance is closely related to human IGF-IEc: the C-terminus has been found to be modified compared to human IGF-IEc by replacing the terminal lysine and arginine residues by a histidine (See Fig 1)

Cell death via mitochondrial apoptotic pathway due to activation of Bax by lysosomal photodamage

Researchers also employ the modified version of DMEM for a wide array of research applications, such as drug discovery, tissue engineering, and the study of cell signaling pathways

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Additional proteins are linked with plasma lipid metabolism, brain and CNS endothelial cell maintenance, and blood pressure regulation and tissue remodeling (kallikrein)