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The only clinical study that was designed to define a harmful threshold involved patients with cardiac arrest in which a PaO 2 threshold of 300 mmHg was identified, but this study was retrospective and other confounders could not be excluded 91
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It is primarily produced in the liver and is known for its potent antioxidant properties
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GPX1 (-,-) mice expressed unchanged levels of GPX4, GPX3 and GPX2, which may particularly substitute for the GPX1 deficiency (50)
