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Sleep spindles are produced by the rhythmic discharge of thalamic relay neurons that induce the onset and maintenance of non-restorative sleep, causing interruptions in sleep continuity [76]

Furthermore, the combination of GLPG0259, an inhibitor of PRAK, with EV-derived miRNAs specifically targeting PRAK exhibits promising potential in mitigating neuroinflammation observed in neurodegenerative disorders like PD

In general, such animal models revealed that low circulating IGF-1 levels are associated with more extensive atherosclerosis (144), whereas high circulating IGF-1 levels are not (9)

Moreover, KGA and GAC also carry distinct 3 and 5 untranslated regions (UTRs) 10

As such, they continue to be the foundation for the study of potential ALS therapeutics [19]

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