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Finally, the design of long-term trials with clinically meaningful endpoints encounters logistical challenges, as demonstrated by the premature termination of numerous phase III studies due to insufficient enrollment or delayed therapeutic effects

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*Correspondence: Jialing Hu, [email protected] Li, [email protected] Mei, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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