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Patients who develop symptoms of unexplained hyperammonemic encephalopathy while receiving valproate therapy should receive prompt treatment (including discontinuation of valproate therapy) and be evaluated for underlying urea cycle disorders (see Contraindications and Hyperammonemia and Encephalopathy Associated with Concomitant Topiramate Use as follows)

Indeed, alterations in nucleus accumbens function have been implicated in disorders that are routinely accompanied by motivational impairments (e.g., depression)

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