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Brain temperature profiles during epidural cooling with the ChillerPad in a monkey model of traumatic brain injury

Wasn't fully characterized until 1935 by Frederick Gowland Hopkins

MECHANISM CATEGORIES SAFETY Side effects Generally well-tolerated in trials at the doses tested Injection-site reactions Known interactions Not characterized in Phase 3 Contraindications Pregnancy/lactation (unstudied) REGULATORY STATUS FDA Not FDA-approved as a drug

However, provided that treatment in the context of acute viral infections is short-termed and therefore fundamentally different from the long-term treatment in diabetes, phenformin could represent a viable treatment option
