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In response to oxidative and nitrosative stress, cells increase their antioxidant defenses through activation of nuclear factor erythroid 2related factor (Nrf2), an important transcription factor (Maes et al., 2011)

Nature 320 (6061), 4546

[DOI] [PMC free article] [PubMed] [Google Scholar] 593.Jia C, Guo Y, Wu FG

doi: 10.1016/j.siny.2017.07.006

Chronic high temperatures can cause the inactivation of protein synthesis and DNA repair processes

3B), induce the recruitment of immune inflammatory cells, NO production, foam cell formation, enhance mitochondrial ROS production, and Mphs secretion of cytokines, such as TNF, IL-12p70, IL-6, IL-10, IFN [114]