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The involvement of IRP2-induced ferroptosis through the p53-SLC7A11-ALOX12 pathway in parkinson's disease

doi:10.1007/s00253-013-5074-8 Kurylenko OO, Yurkiv MT, Dmytruk KV, Sybirnyi AA (2016) Method for producing recombinant strains of methylotrophic yeast Hansenula polymorpha capable of glutathione overexpression

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Recordings were made at room temperature in artificial cerebrospinal fluid (aCSF) (pH 7.3, osmolarity 305 +/- 5 mOsm/kg) perfused at 2 mL/min containing 150 mM NaCl, 10 mM 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid, 10 mM glucose, 3 mM potassium chloride, 2 mM calcium chloride, and 1.3 mM magnesium chloride

Mitochondria are the major producers of intracellular ROS