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PLoS Comput Biol 2021;17:e1009708

In addition, capsaicin is testified to redifferentiate ATC cells by triggering TRPV1-Ca 2+ /cAMP/PKA/CREB cascade pathway, which provides new strategy assisting radioiodine therapy [290]

10.1038/nm.2819 Nat

Castellanos-Garca et al

For this reason, it is generally recommended that the therapeutic regimen be kept as simple as possible, since the risk of adverse effects is lower when one or two agents are given at higher doses as compared to a multiple-drug regimen using lower doses

The authors of one of these papers suggested that isotype switching could allow for HIV-infected individuals to respond to the escape of HIV from neutralization in a phenomenon they termed switch redemption 98