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(2018), demonstrated that in primary cortical neurons Atp7b is distributed in a vesicular pattern around the nucleus and the cytosol while Atp7a was clustered at the axonal side of the nuclei suggesting distinct and non-overlapping localization of these two copper transporters under basal conditions (Schmidt et al., 2018) Intriguingly, in primary hippocampal neurons, treatment with 100 M copper results in movement of Atp7b from the somatodendritic compartment to axons where it was colocalizes with Lamp-1, suggesting that copper treatment drives Atp7b localization to late endosomes or lysosomes for axonal trafficking (Jain et al., 2015)

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