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Side effects also appear to be more common when protocols are overly aggressive or inconsistent

Research has revealed that acute inhibition of the ERK pathway has inconsistent results in inducing depressive-like behavior, and chronic pharmacological inhibition of ERK through repeated infusion of the specific MAPK kinase (MEK) inhibitor U0126 into the hippocampus and mPFC has been shown to cause depressive-like behavior (Einat et al., 2003

doi: 10.1016/S0140-6736(20)32205-4 234 SehlinD.HultqvistG.MichnoW.AguilarX.DahlenA

Abnormal levels of mitochondrial proteins in plasma neuronal extracellular vesicles in major depressive disorder

The glutathionylation/deglutathionylation cycle is viewed as a process that acts primarily against ROS/RNS via reducing aberrant cysteine modifications and thereby preventing the formation of damaging irreversible cysteine modifications