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This led to the assumption that the primary receptors mediating weight loss for this target class were AMYRs, yet, dual agonists are reported to have higher efficacy than AMYR selective agonists 2,10,11,12

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doi: 10.1007/s00726-018-2640-5 37 KalhanSCHansonRW

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Preclinical and clinical studies demonstrate that co-administration of these peptides achieves superior reductions in bodyweight, appetite, and fasting glucose than either agent aloneachieving up to a 17% reduction in bodyweight in non-diabetic individuals and a 15.6% reduction in patients with type 2 diabetes over 2032 weeks
