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Rarely, however, MTHFR activity may be so low that it can result in homocystinuria, leading to abnormal blood clotting, brittle bones, nearsightedness, and increased risk of having a child with a neural tube defect

doi:10.1161/STROKEAHA.107.504498

The first one involves irreversible damage to the ETC, possibly through TTC5 upregulation, resulting in ATP loss, increased mitochondrial superoxide production and caspases 3/7 activation, and subsequent apoptosis

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Doctors prescribe Alimta Injection 500 mg (Pemetrexed) as a chemotherapy drug for treating non-small cell lung cancer (NSCLC) and malignant pleural mesothelioma