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Most side effects peak within the first 12 weeks and significantly improve within 36 weeks as your body adapts to the medication

It also induces the Notch1, Notch3, vascular VEGFR2/KDR, PDGF-BB, ID1 and N-cadherin upregulation and down-regulation of VE-cadherin gene expression, and can lead to the stabilization and maturation of CYR61/CCN1, thus exerting its role in the formation, remodeling and maturation of the blood vessels [92]

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