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Difference Between Melanotan 1 and Melanotan 2 Although often mentioned together, Melanotan 1 and Melanotan 2 are structurally and functionally distinct peptides: Melanotan 1 (Afamelanotide): Higher selectivity for MC1 receptors Primarily associated with pigmentation research Developed with a focus on skin-related applications Melanotan 2: Less receptor-selective (affects multiple melanocortin receptors) Associated with a broader range of biological effects Structurally shorter and more potent at lower doses Because of its receptor selectivity, Melanotan 1 is generally considered more targeted in its mechanism of action compared to Melanotan 2