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Heavy metals that can lead to toxicity (or poisoning) include: Mercury Lead Arsenic Cadmium Aluminum Nickel Uranium Thallium Other definitions include manganese, iron, lithium, zinc and calcium

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Subsequent clinical cases revealed that -synuclein pathology is not only restricted to the soma but also extends to neurites which led to the coinage of the term Lewy neurites ( Under normal physiological conditions -synuclein exists mostly in an N acetylated membrane bound form which results in adoption of an -helical structure (Runfola et al., 2020)