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Assessment of therapeutic efficacy in the treatment of the hyperglycemia in T2D is accomplished by routine measurement of the circulating levels of glycated hemoglobin, designated as the level of HbA 1c , often designated as just A1c

These patients were treated with twice-daily with oral emricasan at 5 mg, 25 mg or 50 mg, or placebo in a 1:1:1:1 ratio for up to 48 weeks

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doi: 10.1001/archopht.121.2.211

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Despite these benefits, long-term LC administration has been associated to cardiovascular risks due its conversion to trimethylamine- N -oxide (TMAO) by the gut microbiota