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These studies suggest that autophagy can amplify ROS generation during ferroptosis by regulating key pathways involved in iron metabolism and lipid peroxidation, such as the p62/SQSTM1-NCOA4 axis and ATG5-mediated signaling

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These cells are poised for immediate response to the pathogen and can execute effector functions, including the release of cytokines and cytotoxic activities, without the requirement for further differentiation (231233)

Detection of cell hypoxia in vitro LLC cells were seeded in a 35 mm confocal dish with a 15 mm bottom well (Cellvis, USA) at a density of 10 5 cells per dish and cultured at 20% O 2 until cell adherence was ensured