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Studies demonstrate FOXO4-DRI achieves comparable renal function restoration to genetic clearance of senescent cells using the p16-3MR suicide gene system, confirming that therapeutic effects result specifically from senescent cell elimination rather than off-target actions

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For perspective, that level of efficacy means someone weighing 220 pounds could expect to lose approximately 53 pounds over 48 weeks

S., Brasch, N

[1] [2] The pharmacological effects of tirzepatide create unique nutritional considerations