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The SMA7 mice that overexpress a muscle specific IGF-I isoform (mIGF-I) display enlarged myofibers and increased median survival, compared with mIGF-I-negative SMA littermates[42]
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Tau, which is normally a microtubule-stabilizing protein, becomes pathogenic after being hyperphosphorylated, thereby compromising neuronal transport systems
[DOI] [PMC free article] [PubMed] [Google Scholar] 247.Tang K.F., Li Y.L., Wang H.Y
Inflamm Res, 2012, 61(5), 445-454
