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However, a larger follow-up pivotal trial, known as METAOD006 (or OPTIONS), enrolled a bigger cohort and failed to replicate statistically significant weight loss, leading the sponsoring company, Metabolic Pharmaceuticals, to halt the formal drug-development program in 2007

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These recent experimental findings are biologically plausible, particularly as both oxidative stress and neuroinflammation are increasingly recognized as important contributors to the pathophysiology of ASD (151, 156, 160)