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A higher risk of deficiency is present in patients with malabsorptive syndrome and/or unusually low sun exposure, those who have undergone gastric bypass surgery, or those on prolonged glucocorticoid use (which alters intestinal absorption) (46)
Furthermore, patients with inflammatory bowel disease have a higher risk of HHcy due to vitamin B deficiency
The oral formulation's convenience advantage over injectable semaglutide would be even more pronounced in pediatric populations, potentially making orforglipron the preferred first-line pharmacological option for adolescent obesity if efficacy and safety data support its use
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doi: 10.1016/j.chom.2022.11.015 128
